Pharmacological Profiles of a Novel Tachykinin NK-2 Receptor Antagonist, TAC-363
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منابع مشابه
Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors.
The tachykinins, substance P, neurokinin A, and neurokinin B, have been implicated in many diseases. The present study evaluated the pharmacological properties of a novel tachykinin antagonist ZD6021 [3-cyano-N-((2S)-2-(3,4-dichlorophenyl)-4-[4-[2-(methyl-(S)-sulfinyl)-phenyl]piperidino]butyl)-N-methyl-]-napthamide]. The affinity (K(i)) of ZD6021 for the cloned human neurokinin (NK)1, NK2, and ...
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The pharmacological and pharmacokinetic profile of SB-222200 [(S)-(-)-N-(alpha-ethylbenzyl)-3-methyl-2-phenylquinoline-4-car boxami de], a human NK-3 receptor (hNK-3R) antagonist, was determined. SB-222200 inhibited (125)I-[MePhe(7)]neurokinin B (NKB) binding to Chinese hamster ovary (CHO) cell membranes stably expressing the hNK-3 receptor (CHO-hNK-3R) with a K(i) = 4.4 nM and antagonized NKB-...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1996
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.116.11_884